We find that, for a very large class of constitutive or-15 thotropic models and with very general assumptions, there is a single linear relationship between 16 a parameter describing the biaxial deformation and cos 2 θ eq, where θ eq is the orientation angle 17 of the cell, with the slope of the line depending on a specific combination of four parameters 18 that characterize the nonlinear constitutive equation. Motivated by the fact that a similar behaviour is observed even for high 13 strains, in this paper we address the problem in the framework of finite elasticity, in order to 14 study the presence of nonlinear effects. Recent experimental findings, also supported 11 by a linear elastic model, indicated that the minimization of an elastic energy might drive this 12 reorientation process. In particular, several experiments have shown that, if a substrate with 9 overlying cells is cyclically stretched, they will reorient to reach a well-defined angle between 10 their major axis and the main stretching direction. 6 The active response of cells to mechanical cues due to their interaction with the environment 7 has been of increasing interest, since it is involved in many physiological phenomena, pathologies, 8 and in tissue engineering.
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